Recommendations of diabetologic society concerning pre-conceptive arrangements in female patients with diabetes type 1 demand a normal HbA_1c level under 4,0 % (according to IFCC). Pregnancy is not recommended in HbA_1c levels higher than 6,5 % because of a high risk of congenital birth defects. The recommendation to terminate the pregnancy in a poorly compensated female diabetic patient belongs to the most complicated ones regardless of a team cooperation of experts in genetics and gynecology. The final decision must be always made by a patient. We present a case history of a 26 years old female patient with the newly diagnosed diabetes mellitus type I in the 7^th week of the first and very expected pregnancy, HbA_1c 11,3 %, actual glucose 20 mmol/l, anti GAD 43,9 U/ml, C-peptide 0,36 ng/ml. According to the expert in genetics it was possible to postpone the pregnancy termination until the 18^th week, while monitoring the laboratory tests and ultrasound. Based on the consultation with the expert in diabetology and pregnancy the patient decided to terminate the pregnancy in the 8^th week.

Key words: pregnancy, diabetes mellitus type 1, congenital birth defect, termination of pregnancy

The case history is intended to demonstrate an association of dementia with the diabetes treatment in subjects of an advanced age. Psychiatric problems are of a serious character and it is important to seek for subjects at risk and to treat them as soon as possible. Yet the history has taught us that the prevention forms an important part of the medicine.

Key words: psychiatric morbidity in elderly, diabetes mellitus, compliance with treatment regimen

There is a high risk of developing premature atherosclerosis and clinical cardiovascular events in obese patients with diabetes type 2. This is particularly caused by a frequent presence of other components of metabolic syndrome in these patients – high insulin resistance, dyslipidemia, hypertension, hypercoagulative status. In our paper we describe a complex treatment of a diabetic patient suffering from all other diseases that comprise the insulin resistance syndrome. Thanks to the complex treatment this patient has reached better compensation of not only diabetes but also dyslipidemia and particularly obesity. The patient has maintained the improvement for a long period. 

Key words: obesity in diabetes mellitus type 2, insulin resistance, combination of insulin and sensitizing agents

We present a case history of a female patient who suddenly developed unconsciousness with seizures that progressed to acute respiratory insufficiency demanding artificial lung ventilation. The problem was caused by a thyreotoxic crisis. Complex intensive treatment including administration of antithyroidal agents resulted in a fast remission.
The paper demonstrates that undiagnosed and consequently untreated thyreotoxicosis can become a life threatening condition even in middle-age subjects.

Key words: thyreotoxic crisis, unconsciousness with seizures, respiratory insufficiency, antithyroidal agents

Adverse effects of commonly used antithyroidal agents (thiourea derivates) are rare, but can be even fatal. We demonstrate the course of two cases of liver damage caused by carbimazol and thiamazol.

Key words: adverse effects of thyroidal blockers, agranulocytosis, liver damage