Authors describe a case of 25-year-old male patient with newly diagnosed diabetes mellitus requiring insulinotherapy in an early course of the disorder. The results of hormonal parameters and finding of the sellar expansion at morphological imaging study confirmed clinical suspicion of acromegaly. As expected, the size and the expansion of pituitary adenoma predicted limited outcome of neurosurgical operation. Opposite to negative effects of somatostatin analogue therapy on glycaemic compensation as stated in literature, following treatment with long-acting octreotide formulation urged us to reduce insulin doses and even to stop insulin treatment during the short treatment period. This case underscores the need for clinical experience in classifying diabetes, determination on treatment modalities, as well as the evaluation of expected positive and negative effects in therapy of disorder underlying the specific type of diabetes.

Key words: diabetes mellitus, acromegaly, other specific type of diabetes, somatostatin analogue, octreotid

The presented paper summarizes a case of a young female patient with hypertension, who despite of maximal antihypertensive treatment was not able to achieve sufficient compensation, and with hypokalemia caused by aldosterone-producing adrenal adenoma in Conn’s syndrome.

Key words: primary hyperaldosteronism, Conn’s syndrome, secondary hypertension, hypokalemia, adrenal adenoma

Nowadays we put stress on the tightest possible compensation of diabetes in quest of preventing particularly late complications of this disease. Despite of its positives, the intensification of the treatment has also the pitfalls. Patient’s compliance can be decreased by excessive demands of the treatment – simple simplification can lead to the improvement of the outcomes. The use of premixed insulins represents a very good option of simplified treatment. 

Key words: premixed insulin aspart, insulin regimen, weight gain, insufficient compensation, compliance

At the occasion of 25th anniversary of pancreas transplantation in Institute of Clinical and Experimental Medicine and 40th anniversary of pancreas transplantation in the world their history is presented.

Key words: pancreas transplantation, diabetes mellitus

We present a case of a male patient with a history of recurrent peptic ulcer disease, who was only after 10 years diagnosed with the primary hyperparathyreosis caused by PTH-producing adenoma. In this paper we would like to point out that primary hyperparathyreosis may be a possible cause of peptic ulcer disease.

Key words: primary hyperparathyreosis, PTH-producing adenoma, hypercalcaemia, peptic ulcer disease

The paper describes two concurrent diseases – Down’s syndrome and type I pseudohypoparathyreosis – in a 15-years-old boy. The treatment was very complicated. The correction of serum Ca level including ionized fraction was constantly unsuccessful. It was partially caused by certain degree of patient’s non-compliance. Dosing with alpha D3 preparation was the only solution of this problem.

Key words: Down’s syndrome, parathormone, hypoparathyreosis, pseudohypoparathyreosis, Tachystin